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Effects of Various Dietary Levels of Selenium as Selenite or Selenomethionine on Tissue Selenium Levels and Glutathione Peroxidase Activity in Rats^1,2,

Department of Agricultural Chemistry, Oregon State University, Corvallis, OR 97331

Weanling rats were fed a basal diet or this diet plus 0.2, 1.0, 2.0 or 4.0 mg/kg selenium (Se) as either selenite or selenomethionine (SeM). Except at the 0.2 mg/kg Se level, Se accumulated in all tissues at higher levels when SeM was fed than when selenite was given, and the magnitude of difference became more pronounced with increasing levels of dietary Se. This was particularly true for muscle and brain. Se levels in whole blood, testes, kidney and lungs were not significantly different between rats fed 0.2 mg/kg Se as selenite or as SeM, but the Se levels in liver, muscle and brain were higher in rats fed SeM. Although the tissue Se concentrations differed markedly, there were no differences in the glutathione peroxidase (GPX) activity in tissues of rats fed SeM rather than selenite. The percentage of Se associated with GPX was lower in all tissues from rats fed SeM than in those from rats fed selenite. These results indicate that the chemical forms of dietary Se can have a marked influence on biological responses, including bioavailability of dietary Se.

KEY WORDS: • glutathione peroxidase • selenite • selenomethionine • selenium • rats

¹ Published with the approval of the Oregon State University Experiment Station as Technical Paper No. 8186.

² Supported by Public Health Service Research Grant No. DK 38306 from the National Institute of Diabetes and Digestive and Kidney Diseases.

Manuscript received 8 September 1987. Revision accepted 26 February 1988.

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