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Retention of Skeletal Fluoride during Bone Turnover in Rats¹

Department of Oral Biology and Program in Biochemistry, School of Dentistry, University of Minnesota, Minneapolis, MN 55455

Deposition of fluoride (F) in the skeleton is a major factor in the metabolic regulation of F. The progressive increase in bone F levels with age suggests that F is rather firmly sequestered once it is deposited in bone. We have examined the extent to which F is resorbed and redeposited during bone turnover in growing rats. The skeleton was first preloaded with F by intake of water containing a high level of F (50 mg F/L) and simultaneously labeled with [³H]tetracycline (³H-TC) to provide a measure of subsequent bone turnover. Rats were then changed to a very low F intake, and bone F loss was compared with ³H-TC loss in animals undergoing normal bone turnover or turnover accelerated by a low calcium (Ca) intake. Approximately 60% of F mobilized during bone resorption was redeposited in the skeleton (humerus and vertebrae). The redeposition of F showed a positive correlation with mineral deposition. Thus the retention of F in the skeleton of growing rats results predominantly from redeposition of resorbed F rather than passive retention associated with low bone turnover.

KEY WORDS: • fluoride • bone

¹ This study was supported in part by Grant No. DE 01850 from the National Institutes of Health.

² Current address: School of Dentistry, National Taiwan University, Taipei, Taiwan.

³ To whom correspondence and reprint requests should be sent.

Manuscript received 16 April 1987. Revision accepted 9 November 1987.

This article has been cited by other articles:

				J. Nopakun, M.K. Guo, H.H. Messer, and R.H. Ophaug Fluoride Redeposition and Retention during Bone Turnover in Lactating Rats Journal of Dental Research, September 1, 1988; 67(9): 1213 - 1216. [Abstract] [PDF]