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Mitochondrial Function in Rats Is Affected by Modification of Membrane Phospholipids with Dietary Sardine Oil¹

Research Institute for Food Science, Kyoto University, Uji, Kyoto 611, Japan

Phospholipids of heart and liver of rats fed a diet containing sardine oil had more 3 polyunsaturated fatty acids and less 6 polyunsaturated fatty acids than those of rats fed corn oil, whereas there was little difference in the fatty acid composition of brain phospholipids. The mass of phospholipid classes in rat heart mitochondria was not changed, but their fatty acid compositions were altered. Modification of the fatty acid compositions of mitochondrial phosphatidylcholine and phosphatidylethanolamine reached a plateau after 10 d of feeding, but that of cardiolipin continued for 30 d. The O₂ consumption rate of rat heart mitochondria decreased as the fatty acid composition of the phospholipids changed. This may be due to the reduction of the activity of cytochrome c oxidase, which requires cardiolipin for its activity. However, F₁F_o-ATPase, which also requires cardiolipin, was activated under the same conditions.

KEY WORDS: • dietary sardine oil • tissue phospholipid fatty acids • heart mitochondrial cardiolipin • oxidative phosphorylation

¹ This research was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture of Japan, and by Special Coordination Funds for Promoting Science and Technology from the Science and Technology Agency of Japan.

² To whom all correspondence should be addressed.

Manuscript received 13 July 1987. Revision accepted 19 November 1987.

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