Journal of Nutrition OpenSOurce Diets- www.ResearchDiets.com

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

Journal of Nutrition Vol. 118 No. 12 December 1988, pp. 1517-1521
Copyright © 1988 by American Society for Nutrition
This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Davidsson, L.
Right arrow Articles by Sandström, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Davidsson, L.
Right arrow Articles by Sandström, B.

Intrinsic and Extrinsic Labeling for Studies of Manganese Absorption in Humans1,2,

Lena Davidsson, Åke Cederblad, Einar Hagebø3, Bo Lönnerdal4 and Brittmarie Sandström

Departments of Clinical Nutrition and Radiation Physics, University of Gothenburg, Sahlgrenska Hospital, S-413 45 Göteborg, Sweden

A dual-radioisotope method was used to simultaneously study whole-body manganese retention from a chicken liver based meal intrinsically labeled with 54Mn and extrinsically labeled with 52Mn. Manganese retention was monitored in a sensitive whole-body counter during approximately 30 d in six young adult women. Both radio-isotopes were retained to a similar degree and excreted at identical rates. Retention at d 5 was 14.4 ± 10.3 and 14.0 ± 9.9% while retention at d 10 was 5.0 ± 3.1 and 5.0 ± 3.0% (X ± SD) for 54Mn and 52Mn, respectively. From these results we conclude that the intrinsic and extrinsic Mn isotopes did form a common pool before absorption. The results can therefore be regarded as a direct validation of the use of extrinsic labeling for studies of Mn retention for estimating Mn absorption in man.

KEY WORDS: • manganese • retention • whole-body counting • human

1 Research for this study was supported by the U.S. Department of Agriculture, USDA Grant No. 85-CRCR-1-1582.

2 Presented in part at the Second Nordic Symposium of Trace Elements in Human Health and Disease, August 17–21, 1987, Odense, Denmark.

3 Present address: Department of Chemistry, University of Oslo, 0315 Oslo 3, Norway.

4 Present address: Department of Nutrition, University of California, Davis, CA 95616.

Manuscript received 3 March 1988. Revision accepted 12 July 1988.






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]