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Modulation of Age-Related Changes in Serum 1,25-Dihydroxyvitamin D and Parathyroid Hormone by Dietary Restriction of Fischer 344 Rats¹

H. James Armbrecht^*,, Randy Strong^*,, Monica Boltz^*, David Rocco^*, W. Gibson Wood^*, and Arlan Richardson

^* Geriatric Research, Education and Clinical Center, Veterans Administration Medical Center, St. Louis, MO 63125 Departments of Internal Medicine, Biochemistry, Pharmacology and Neurology, St. Louis University School of Medicine, St. Louis, MO 63104 Department of Chemistry, Illinois State University, Normal, IL 61761

The purpose of this study was to determine the effect of food restriction on age-related changes in serum 1,25-dihydroxyvitamin D and PTH, two important regulators of Ca metabolism. Starting at 6 wk, male F344 rats were fed a purified diet either ad libitum (non-restricted) or 60% of ad libitum (restricted). Rats from each group were killed at 5, 13, 22 and 28 mo of age. Dietary restriction increased the median lifespan from 24 to 31 mo. It delayed the rapid decrease in serum 1,25-dihydroxyvitamin D from 1.5–5.0 mo in the non-restricted group to 5–13 mo in the restricted group. It also completely suppressed the marked rise in serum PTH which occurred at 22 and 28 mo in the non-restricted group. Dietary restriction had these effects even though both groups of animals consumed the same amount of Ca per gram body weight. Diet had no effect on serum Ca and P, except at 28 mo. These effects of dietary restriction on serum 1,25-dihydroxyvitamin D and PTH may result in altered Ca metabolism in dietary restricted F344 rats.

KEY WORDS: • dietary restriction • aging • 1,25-dihydroxyvitamin D • 25-hydroxyvitamin D • parathyroid hormone

¹ This work was supported by the Medical Research Service and the Geriatric Research, Education, and Clinical Center for the Veterans Administration and by NIH Grants Nos. AM32158 (H. J. A.) and AGO1548 (A. R., R. S.)

Manuscript received 20 November 1987. Revision accepted 20 July 1988.

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