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The Effect of Past and Current Dietary Zn Intake on Zn Absorption and Endogenous Excretion in the Rat

United States Department of Agriculture, Agricultural Research Service, Human Nutrition Research Center, P.O.Box 7166, University Station, Grand Forks, North Dakota 58202

Effects of previous dietary Zn (or body Zn stores) and current dietary Zn intake on absorption and endogenous excretion of Zn were studied by using radioisotope dilution. Rats were fed diets containing 1.5, 12.6 or 50.3 mg Zn/kg for 19 d (dietary period I). Total body Zn in the three groups was 1870 ± 340, 3953 ± 698 and 4126 ± 844 µg Zn/rat. Each group was divided into four subgroups fed 3.6, 12.6, 20.5 or 50.3 mg Zn/kg diet for 3 wk (dietary period II). Rats were injected intramuscularly with ⁶⁵Zn after 7 d of dietary period II. True absorption and endogenous excretion were calculated by isotope dilution. Zinc intake, urinary and fecal excretion, balance and percent Zn absorption were significantly affected only by dietary Zn in dietary period II (P < 0.01). Endogenous excretion was affected by both past dietary Zn deficiency (body Zn stores) and by dietary Zn in dietary period II (P = 0.0001). Total body Zn at the end of the experiment was significantly affected by both periods of dietary treatment (P < 0.001), but total body Zn concentration was affected only by the final dietary treatment (P < 0.05). These results show that Zn absorption is affected by the current diet, but that turnover of Zn (endogenous excretion) is regulated by both curent Zn intake and past Zn intake, probably through an effect on body Zn stores.

KEY WORDS: • Zn absorption • excretion • homeostasis • Zn stores

Manuscript received 7 April 1988. Revision accepted 8 August 1988.

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