QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Aubert, R. Articles by Lemonnier, D. Search for Related Content PubMed PubMed Citation Articles by Aubert, R. Articles by Lemonnier, D.

Serum Lipoprotein Profiles in Mice: Effects of Early Over- and Undernutrition

INSERM, Unité 1, Hôpital Bichat, 77877 Paris Cedex 18, France

Effects of early over- and undernutrition on lipoprotein profiles of adult Swiss male mice reared in litters of different sizes were investigated. Lipoproteins were isolated by density gradient ultracentrifugation and defined by chemical composition. Protein moieties were defined by their charges. The lipoprotein lipase (LPL) activity in epididymal adipose tissue, heart and diaphragm was measured. Early feeding patterns induced permanent body weight differences in adult mice. Serum phospholipid content was significantly higher in obese than in control mice. Overfeeding led to significantly higher activity of LPL in adipose tissue; inversely, undernutrition induced a lower LPL activity. There was a trend toward variations of lipoprotein concentrations in relation to litter size, with significant differences being observed only between obese and undernourished mice for LDL-HDL₁ (low density lipoprotein—high density lipoprotein) and HDL₂ concentrations. Compared with normally fed mice the most notable alterations in plasma lipoprotein composition were, in LDL-HDL₁, greater cholesteryl ester in obese and less phospholipid in undernourished mice. In contrast, tetramethylurea-soluble apolipoprotein distribution was unaffected by litter size. Although moderate differences were observed in lipoprotein compositions and levels in over- or undernourished mice, further investigations of lipoprotein metabolism and metabolic abnormalities in this animal model are required.

KEY WORDS: • nutrition • neonate • litter size • lipoproteins • apolipoproteins • lipoprotein lipase

Manuscript received 26 April 1988. Revision accepted 24 May 1988.