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Bioavailability of Vitamin B-6 from Rat Diets Containing Wheat Bran or Cellulose^1,2,

U.S. Department of Agriculture, Western Regional Research Center, Albany, CA 94710

Bioavailability of vitamin B-6 (B-6) in the total diet was studied in male, weanling Sprague-Dawley rats fed fiber-free (FF) diets with 0, 2 or 6.9 mg pyridoxine/kg diet (0-, 2- or 6.9-PYR), 20% wheat bran (WB) diets with 3.9- or 5.5-PYR or 7% cellulose (C) diets with 0- or 2-PYR for 28 d. Body weight gain (mean ± SEM) with 0-PYR was 70 ± 9.0 and 81.2 ± 4.2 g for FF and C, respectively. All other groups gained 170–180 g. Urinary excretion of 4-pyridoxic acid (4-PA), a major B-6 metabolite, for FF groups was 1.31 ± 0.22, 2.26 ± 0.28 and 6.39 ± 1.73 µg/24 h, at 0-, 2- and 6.9-PYR, respectively. Rats fed WB diets excreted 4.99 ± 0.58 and 9.81 ± 0.76 µg/24 h (3.9- and 5.5-PYR, respectively) and those fed C diets excreted 1.46 ± 0.34 and 2.69 ± 0.72 µg/24 h (0- and 2-PYR). There was increasing turnover and shorter biological half-life of [¹⁴C]pyridoxine (1 µCi injected on d 1) with increasing dietary B-6. Growth, 4-PA and ¹⁴C turnover data indicated that WB contributed to B-6 intake of these rats. Cellulose acted as a simple dietary diluent and had no effect on indices of B-6 status. These data suggest that dietary fiber, as cellulose or the indigestible component of wheat bran, does not adversely affect the bioavailability of vitamin B-6.

KEY WORDS: • vitamin B-6 • bioavailability • wheat bran • dietary fiber

¹ Presented in part at the 71st Annual Meeting of the American Association of Cereal Chemists, Toronto, Ontario, October 5–9, 1986 [Cereal Foods World 31: 590 (abs.)].

² Mention of firm names or specific products does not constitute endorsement by U.S. Department of Agriculture and does not imply recommendation over others that may be suitable.

³ To whom reprint requests should be addressed.

⁴ Present address: Department of Nutritional Sciences, University of California, Berkeley, CA 94720.

Manuscript received 3 December 1986. Revision accepted 28 September 1987.