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Sodium Deprivation Growth Failure in the Rat: Alterations in Tissue Composition and Fluid Spaces

Divisions of Nephrology and Cardiology, Department of Pediatrics, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, Newark, NJ 07103-2757

Dietary control of sodium intake was utilized in weanling rats to study the relationships among body growth, tissue composition and extracellular fluid volume (ECFV). Forty 3-wk-old rats were divided into groups receiving 30, 150, 300, 600 or 900 µeq sodium/d for 5 wk. The minimal daily requirement for normal growth was 300 µeq Na, or about 60 µeq/g of new growth. Lower doses caused dose-related growth failure associated with a reduced ECFV. Analyses of carcass, muscle and bone composition were carried out. In sodium-deprived animals there was retarded growth of protoplasm, fat and bone; the mineral composition of muscle was not altered, whereas in bone calcium concentration was reduced. Plasma concentrations of sodium, potassium and chloride remained normal. Pair-feeding indicated that sodium-deficiency growth retardation could not be attributed to starvation. Sodium-deficient animals ingested a greater amount of food per gram of weight gain, possibly reflecting an increased energy expenditure. Sodium deprivation initially permitted protoplasmic growth to proceed at a rate disproportionate to that of the ECFV. Subsequently, both continued to grow at a reduced but similar rate, suggesting that ECFV may be a controller of protoplasmic growth.

KEY WORDS: • diet • sodium • growth • extracellular fluid • body composition

Manuscript received 20 October 1986. Revision accepted 4 May 1987.

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