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Crucial Dietary Factors in Maximizing Life Span and Longevity in Autoimmune-Prone Mice¹

Oklahoma Medical Research Foundation, Oklahoma City, OK 73104 and All Children's Hospital, Department of Pediatrics, University of South Florida, St. Petersburg, FL 33701

When the energy intake of (NZB x NZW)F₁ female mice was reduced to 60% of the intake of simultaneously ad libitum-fed mice, the early death associated with autoimmune-based renal disease in this strain was greatly delayed. The length of prolongation of disease-free life depended not only on the decreased energy intake but also on the energy source. In the group of mice with 60% intake of a carbohydrate-free (i.e., high fat) diet, mean longevity was doubled as compared to that of ad libitum-fed mice. However, when the nonprotein energy was supplied by carbohydrate (sucrose and glycerol) the mean longevity was three times that of the ad libitum-fed groups, although survival times varied widely. With ad libitum feeding the nonprotein energy source did not significantly affect longevity. Clearly, although energy intake restriction provides significant influence on longevity, very high fat diets do not give the same protection as do high carbohydrate diets. The basis for this difference is not entirely clear and several explanations are possible.

KEY WORDS: • high fat • high carbohydrate • longevity • renal disease • autoimmunities

¹ This work was supported by grants from the National Institutes of Health (AGO5633, AGO5628 and AI22360), The Florida Chapter of the American Heart Association, The Research Foundation of United Sciences of America and the Oklahoma Arthritis Foundation.

² Present address: The National Minamifukuoka Chest Hospital, Fukuoka, Japan 815.

Manuscript received 2 September 1986. Revision accepted 12 February 1987.

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