Journal of Nutrition OpenSOurce Diets- www.ResearchDiets.com

Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
QUICK SEARCH:   [advanced]


     

Journal of Nutrition Vol. 117 No. 6 June 1987, pp. 1121-1128
Copyright © 1987 by American Society for Nutrition
This Article
Right arrow Full Text (PDF)
Right arrow Purchase Article
Right arrow View Shopping Cart
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Romsos, D. R.
Right arrow Articles by Grogan, C. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Romsos, D. R.
Right arrow Articles by Grogan, C. K.

Energy Balance in Rats with Obesity-Producing Hypothalamic Knife Cuts: Effects of Adrenalectomy1

Dale R. Romsos, Jerry G. Vander Tuig2, Janos Kerner and Colleen K. Grogan

Department of Food Science and Human Nutrition, Michigan State University, East Lansing, MI 48824-1224

Rats with obesity-producing, hypothalamic knife cuts (KC) were fed a purified high fat diet for 9 wk. KC rats consumed more energy (+70–100%) and retained energy with a much higher efficiency than control rats. Adrenalectomy of KC rats 1 wk (before gross obesity was evident) or 5 wk (when KC rats were 70% overweight) after KC surgery caused a reduction in energy intake to levels approximating those of control rats. Furthermore, energy retention in adrenalectomized KC rats was depressed more than could be explained on the basis of the reduction in energy intake. Two factors associated with the reduction in energy retention, urinary excretion of norepinephrine, an indicator of sympathetic nervous system activity, and GDP binding to brown adipose tissue mitochondria, an indicator of the thermogenic capacity of the tissue, were higher in vadrenalectomized KC rats than in pair-fed KC rats. Removal of the adrenals not only suppressed hyperphagia in KC rats fed a high fat diet, but also increased energy expenditure per kilocalorie consumed.

KEY WORDS: • high fat diet • brown adipose tissue • urinary norepinephrine • energy balance

1 Supported in part by National Institutes of Health Grant No. AM-15847. Michigan Agricultural Experiment Station journal article 11601.

2 Present address: Lincoln University, Jefferson City, MO 65101.

Manuscript received 3 November 1986. Revision accepted 12 February 1987.






Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]