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Effects of Maternal Dietary Restriction in Vitamin B-6 on Neocortex Development in Rats: B-6 Vitamer Concentrations, Volume and Cell Estimates^1,2,3,

Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907

Influence of the time of maternal restriction in dietary vitamin B-6 on vitamer concentrations and morphological development of neocortex was examined. Rats were fed ad libitum a vitamin B-6—free diet supplemented with 0.0 or 0.6 mg pyridoxine hydrochloride (PN·HCl)/kg diet during gestation followed by a control diet (7.0 mg PN·HCl/kg) during lactation or were supplemented with 0.6 or 7.0 mg PN·HCl/kg diet throughout gestation and lactation. During postweaning offspring received the maternal diets fed during lactation. Neocortices of offspring were examined at 30 d of age by liquid chromatography and light microscopy. Vitamin restriction during gestation and 30 d postnatal was the only vitamin B-6—restricted treatment of the three administered that altered B-6 vitamer levels in neocortex; all vitamers were depressed equally. Brain weight and volume of neocortex were not changed significantly by the maternal restrictions imposed. However, each restriction adversely affected neurogenesis and neuron longevity of the neocortex and when expressed as percent reduction from control, neuron longevity was affected more severely than neurogenesis.

KEY WORDS: • vitamin B-6 • pyridoxine • brain • neocortex

¹ Paper No. 10,799 of the Purdue University Agricultural Experiment Station, West Lafayette, IN 47907.

² Supported in part by U.S. Public Health Service Grant NS-14005.

³ Presented in part at the 1986 Annual Meeting of the Federation of American Societies for Experimental Biology, St. Louis, MO, April 13–18. Groziak, S. M. & Kirksey, A. (1986) Effect of maternal vitamin B-6 restriction on the development of the cerebral cortex. Fed. Proc. 45: 824 (abs.).

⁴ To whom requests for reprints should be sent.

Manuscript received 21 July 1986. Revision accepted 2 February 1987.