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Journal of Nutrition Vol. 117 No. 4 April 1987, pp. 717-724
Copyright © 1987 by American Society for Nutrition
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Mineral Utilization by Rats Fed Various Commercially Available Calcium Supplements or Milk1,2,

J. L. Greger, Catherine E. Krzykowski, Reem R. Khazen and Connie L. Krashoc

Department of Nutritional Sciences, University of Wisconsin, Madison, WI 53706

The effects of commercially available calcium supplements and milk on tissue levels and apparent absorption of calcium, magnesium, phosphorus, zinc, iron and copper were evaluated in two studies with rats. Calcium supplements (calcium phosphate dibasic, oyster shell preparations with and without supplemental magnesium, calcium lactate, calcium carbonate with and without supplemental iron and vitamins, dolomite and chelated calcium with and without chelated magnesium) and nonfat dry milk were the sole sources of calcium in nutritionally adequate diets. Rats fed calcium phosphate dibasic had enlarged kidneys with >20-fold increases in calcium levels. The rats fed the three magnesium-fortified supplements had lower apparent absorption of calcium and iron and less accumulation of calcium in bone than rats fed milk. There were few differences in the utilization of calcium by rats fed milk or supplements containing only calcium lactate, chelated calcium, oyster shells and calcium carbonate, but magnesium retention in bone was greater among rats fed milk.


KEY WORDS: • calcium • milk • bioavailability • calcium supplements

1 This work was supported by the College of Agricultural and Life Sciences, University of Wisconsin-Madison, Project No. 2623, the National Dairy Board in cooperation with the National Dairy Council and the Wisconsin Milk Marketing Board.

2 Some of these data were presented at the 1986 Annual Meeting of the Federation of the American Societies for Experimental Biology, St. Louis, MO, April 13–18. KRZYKOWSKI, C. E., KHAZEN, R. R., KRASHOC, C. L., KAISAKI, P. J. & GREGER, J. L. (1986) Mineral utilization in rats fed various commercially available calcium supplements or milk. Fed. Proc. 45: 374 (abs.).

Manuscript received 10 June 1986. Revision accepted 25 November 1986.







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