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The Disaccharide Effect of Sucrose Feeding on Excretion of Intravenously Injected [1,2-³H]Aldosterone and Conjugated Glucuronic Acid in Normotensive Rats¹

Department of Food, Nutrition and Institution Administration, College of Human Ecology and Department of Animal Science, College of Agriculture, University of Maryland, College Park, MD 20742

The hypothesis tested was that feeding rats sucrose rather than invert sugar (50:50 mixture of glucose and fructose) or comstarch would result in a more rapid excretion of glucuronides and tritium from intravenously injected [1,2-³H]aldosterone. Thirty 56-d-old male rats of the Sprague-Dawley strain were fed for 8 wk one of three diets containing 45% of dietary energy from sucrose, invert sugar or comstarch; 15% of energy was from protein and 40% from fat. Body weights and systolic blood pressures were measured weekly. After 60 d of feeding the diets ad libitum, all rats were injected intravenously with [1,2-³H]aldosterone and the percent recovery of tritium in both urine and feces was determined over the next 4 d. Urinary and fecal excretion of both free and conjugated glucuronic acid was determined over those 4 d. Urinary excretion of sodium and potassium (mg/d) was also determined. There were no differences between groups in food or water intakes, body weights, systolic blood pressures, daily fecal weights and daily urine volumes. The cornstarch-fed group excreted less sodium and potassium than did the other groups (P < 0.05). The sucrose-fed group had a greater 4-d excretion of tritium (urinary + fecal) than did the invert sugar- or cornstarch-fed groups (P < 0.01). The sucrose-fed group had a greater percentage of excreted glucuronic acid that was conjugated (urinary + fecal) than did the invert sugar- or cornstarch-fed groups (P < 0.05). These results tended to confirm the hypothesis.

KEY WORDS: • sucrose • aldosterone • glucuronides • sodium • potassium

¹ Computer time was made available by the University of Maryland Computer Science Center.

² Data are from two theses submitted in partial fulfillment of the requirements for the M.S. degree.

³ Present address: 1403 Harrison Hills, Danville, IL 61832.

⁴ Present address: Biospherics, Inc., 4928 Wyaconda Road, Rockville, MD 20852.

Manuscript received 15 August 1986. Revision accepted 2 December 1986.