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Effects of Long-Term Moderate Food Restriction on Growth, Serum Factors, Lipogenic Enzymes and Adipocyte Glucose Metabolism in Lean and Obese Zucker Rats¹

The Hormel Institute, University of Minnesota, Austin, MN 55912 and Department of Surgery, Jefferson Medical College, Philadelphia, PA 19107

The effects of long-term moderate food restriction were assessed in lean and obese male Zucker rats. A 30% reduction in food intake from 5 to 68 wk of age resulted in parallel lowering of body weight in both lean and obese rats compared to their respective ad libitum-fed control groups. In lean rats, epididymal and retroperitoneal fat pad weights and cell size were lowered by food restriction. In obese rats there was an effect of food restriction on growth of the epididymal pad but not the retroperitoneal pad. Hyperinsulinemia, hyperlipidemia and elevated serum albumin levels, as well as higher activity of lipogenic enzymes, were also not affected by food restriction in the obese rat. In a second experiment, long-term food restriction resulted in greater glucose conversion to CO₂ in response to insulin in adipocytes from lean rats but not obese rats compared to their respective control groups. These results indicate that food restriction throughout the first year of life in the obese Zucker rat does not alter the development of hyperplastic obesity and insulin resistance.

KEY WORDS: • food restriction • adipose tissue • lipogenic enzymes • glucose metabolism • growth

¹ Supported by NIH Grant AM 32965 from the National Institute of Arthritis, Diabetes, Digestive, and Kidney Diseases and by the Hormel Foundation.

Manuscript received 12 June 1986. Revision accepted 30 September 1986.

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