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Alterations of Pancreatic Digestive Enzyme Content in the Manganese-Deficient Rat^1,2,3,

Patsy M. Brannon^*, Victoria P. Collins^* and Murray Korc

^* Departments of Nutrition and Food Science Internal Medicine University of Arizona, Tucson, AZ 85721

Previous studies suggest that manganese (Mn) may regulate pancreatic exocrine function. In this study, the effects of Mn deficiency on the pancreatic exocrine enzyme content and postweaning development were examined in male weanling Sprague-Dawley rats fed a high carbohydrate diet with 40 ppm Mn (control) or 0.5 ppm Mn (Mn deficient) for 1–10 wk. Pancreatic and hepatic Mn content were 50 and 39% of respective controls in Mn-deficient rats at wk 4. Pancreatic amylase activity was significantly (P < 0.05) higher at wk 8 and 10 in Mn-deficient rats than in controls. Mn deficiency did not alter pancreatic lipase, chymotrypsin or trypsin activities. Dietary Mn repletion restored pancreatic Mn content but did not reverse the elevated pancreatic amylase. These results suggest that Mn may play a complex role in the postweaning development of the exocrine pancreas and the regulation of pancreatic amylase.

KEY WORDS: • manganese • exocrine pancrease • amylase • lipase • trypsin

¹ This research supported in part by Hatch Project 174076 of the Arizona Agriculture Experiment Station to PMB, National Institutes of Health Research Grant AM-32561 to M. Korc from the National Institute of Arthritis, Diabetes, Digestive and Kidney Disease, and a Biomedical Research Support Grant to P.M. Brannon.

² Presented in part at the 69th Annual Meeting of FASEB, Anaheim, April. Collins, V.P., Korc, M. & Brannon, P.M. (1985) Effects of manganese deficiency on the exocrine pancreas. Fed. Proc. 44: 1849 (abs.).

³ Part of a thesis submitted by V.P. Collins to the Graduate College of the University of Arizona in partial fulfillment of the requirements for the M.S. degree for the Graduate Group in Nutritional Sciences.

Manuscript received 27 January 1986. Revision accepted 15 October 1986.