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Effect of Exercise on Riboflavin Status of Rats^{1, 2, 3,}

Department of Human Nutrition, College for Human Development, Syracuse University, Syracuse, NY 13244-1250

The effect of exercise on the riboflavin status of male rats was studied after 6 or 8 wk of treadmill running. Sedentary and exercised rats were pair fed diets marginal in riboflavin (2.0 or 2.5 mg/kg), and their tissue riboflavin concentrations and erythrocyte glutathione reductase activity coefficients (EGRAC) were compared. The rats exercised for 8 wk had similar body weights but significantly greater weights for heart, gastrocnemius and soleus muscles, less epididymal fat and more total muscle nitrogen and riboflavin than their sedentary controls. Similar changes were evident after 6 wk of exercise, but some were not statistically significant. The EGRAC values of both exercised and sedentary rats responded to changes in dietary riboflavin but were not different from each other. The specific activity of mitochondrial acyl-CoA dehydrogenase (per milligram protein) of the soleus muscle was unaffected by exercise; however, when expressed per gram of tissue or per muscle, the activities in exercised rats were 25% (P<0.05) and 60% (P<0.01) higher, respectively, than in sedentary rats. On the basis of the riboflavin-dependent parameters measured in this study, exercise did not increase the dietary riboflavin requirement of growing rats but did increase total riboflavin retention in gastrocnemius and soleus muscles.

KEY WORDS: • exercise • riboflavin • growing rats • erythrocyte glutathione reductase activity coefficient

¹ Supported, in part, by the National Institute of Health, BSRG Grant No. S07 RR077068-18.

² Presented, in part, at the Annual Meeting of the Federation of American Societies for Experimental Biology, Anaheim, CA, 1985. Fed. Proc. 44: 1282 (abs.).

³ Based, partially, on the thesis submitted by K. E. L. Hunter to the Graduate School of Syracuse University, for the M.S. degree.

⁴ To whom reprint requests should be sent.

Manuscript received 24 June 1986. Revision accepted 30 September 1986.