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Modulation of the Flavin-Containing Monooxygenase in Guinea Pigs by Ascorbic Acid and Food Restriction¹

Department of Pharmacology and Department of Environmental and Industrial Health, University of Michigan, Ann Arbor MI 48109

Modulation of the flavin-containing monooxygenase (FMO) by varying the ascorbic acid and food intake was investigated. Hepatic activity of the FMO in ascorbic acid-deficient guinea pigs fed a restricted amount of diet, which resulted in a 10–15% body weight loss, was 17% of that in animals fed restricted amounts of the adequate diet. FMO hepatic activity in ascorbic acid-supplemented guinea pigs on a food-restricted regimen was 176% of that found in animals fed the adequate diet ad libitum. This increase in activity was not related to stress. Alteration in the activity of this important drug-metabolizing enzyme system by a combination of ascorbic acid deficiency and reduced food intake could potentially alter the rate of metabolism of a great variety of pharmaceutical drugs and environmental chemicals.

KEY WORDS: • FAD-monooxygenase • ascorbic acid • food restriction

¹ This work was supported, in part, by Grant 23007 from Hoffmann-La Roche, Inc., Nutley, NJ.

Manuscript received 12 May 1986. Revision accepted 15 September 1986.