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Effects of Manganese Deficiency and Dietary Composition on Rat Pancreatic Enzyme Content^1,2,

Departments of Nutrition and Food Science ^* Internal Medicine, University of Arizona, Tucson, AZ 85721

Recent studies show that manganese (Mn) deficiency increases pancreatic amylase content. Pancreatic adaptation to dietary composition also alters enzyme content. The present study investigated whether Mn deficiency alters pancreatic adaptation to diet. Weanling rats that were fed for 6 wk a high carbohydrate (HC) diet with <1 mg Mn/kg diet (Mn deficient) or 40 mg Mn/kg diet (control) were divided into three control and deficient dietary subgroups: 1) HC, 2) high protein (HP) or 3) high fat (HF). Rats were then fed these diets for 10 d. Body weights and food consumption were comparable among the groups. Pancreatic and hepatic Mn contents were significantly lower in Mn-deficient rats than in respective controls. Digestive enzymes adapted to diet in both control and Mn-deficient rats with the greatest amylase, lipase and trypsin activities in HC, HF and HP rats, respectively. Mn deficiency resulted in significantly greater amylase activity in HC and HP groups and lipase activity in only the HF group than in respective controls. These data suggest that Mn participates in the regulation of pancreatic amylase content and in the adaptive response of pancreatic lipase to dietary fat.

KEY WORDS: • manganese • exocrine pancreas • dietary adaptation • amylase • lipase

¹ This research was supported in part by the National Institutes of Health Grant No. AM-32561.

² Presented in part at the 70th Annual Meeting of the Federation of American Societies for Experimental Biology, St. Louis, MO, April, 1986 [Werner, L., Korc, M. & Brannon, P. M. (1986) Effects of manganese deficiency on dietary adaptation of the pancreas. Fed. Proc. 45: 368 (abs.)].

³ Part of a thesis submitted to the Graduate College of the University of Arizona and the Graduate Group on Nutritional Sciences in partial fulfillment of the requirements for the M.S. degree.

Manuscript received 19 February 1987. Revision accepted 10 August 1987.