QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Ney, D. M. Articles by Schneeman, B. O. Search for Related Content PubMed PubMed Citation Articles by Ney, D. M. Articles by Schneeman, B. O.

Reduction in Plasma Apolipoprotein E and HDL₁ Levels in Rats with Essential Fatty Acid Deficiency¹

Department of Nutrition ^* Department of Dermatology, School of Medicine, University of California, Davis, CA 95616

Rats were fed linoleate- or triolein-supplemented total parenteral solutions by continuous intragastric infusion for 7 or 14 d to characterize plasma lipid and apolipoprotein (apo) levels, and the high density lipoprotein (HDL) profile associated with essential fatty acid deficiency (EFAD). Results indicate that plasma cholesterol and triglyceride levels tend to be lower with EFAD, whereas plasma levels of apolipoproteins E and B are lower and apo A-I levels are higher in EFAD animals. EFAD was also associated with 30% fewer apo E-enriched HDL₁ particles and a decrease from 11.4 to 11.1 nm in the mean peak diameter of HDL (P < 0.05). These observations emphasize the sensitivity of apo E content to alterations in plasma cholesterol level and suggest that cholesterol transport is decreased during EFAD in the rat.

KEY WORDS: • essential fatty acids • lipoproteins • gastric infusion • apolipoproteins

¹ Supported in part by National Institutes of Health Grant No. AM 20446.

² Current address: Department of Nutritional Sciences, University of Wisconsin, Madison, WI 53706.

³ To whom reprint requests should be addressed.

Manuscript received 3 February 1987. Revision accepted 7 August 1987.