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Response of Activity of Jejunal Disaccharidases and Pancreatic Amylase in Young and Middle-Aged Rats to a High Carbohydrate Diet¹

William Thornburg, Judy Grimes, Toshinao Goda, Sergio Bustamante, Paul Pollack and Otakar Koldovsk

Perinatology and Nutritional Sciences Section, Departments of Pediatrics and Physiology, University of Arizona Health Sciences Center, Tucson, AZ 85724

Sprague-Dawiey rats fed a nonpurified diet from weaning to 3 mo (young) or 12 mo (middle aged) of age were fed a low (5 cal%) starch (LST) purified diet for 2 wk. They were then fed a high (70 cal%) starch (HST) purified diet for up to 4 wk. Body weights of both age groups were greater in rats fed the LST than in those fed nonpurified diet throughout. The young, but not the middle-aged, group continued this gain while consuming HST. The levels of activity of intestinal disaccharidases of upper (proximal one-third) and lower (middle one-third) jejunum, and pancreatic -amylase were lower in rats fed LST diet in both age groups than in rats fed HST. Similar increases of specific (per protein or DNA) activity were observed in both age groups throughout the first three (disaccharidase) to four (pancreatic -amylase) days of feeding HST. Values of specific activity of the middle-aged group returned to initial levels with continued feeding of HST. In contrast, values in the young group tended to plateau (disaccharidases) or continued to increase (-amylase). Differences in adaptability over 1 mo were most dramatic for -amylase and sucrase, but negligible for lactase.

KEY WORDS: • lactase • sucrase • maltase • jejunum • body weight

¹ Supported by National Institutes of Health Grant AM 27624, and University of Arizona Grant on Gerontology 410379.

Manuscript received 25 November 1985. Revision accepted 18 August 1986.