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Involvement of Metallothionein in the Hepatic Metabolism of Copper

Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB, United Kingdom

Metallothionein (MT) is often a major copper-binding protein in the liver, particularly of copper-loaded animals. This review describes the isolation of hepatic copper-MT, its physicochemical properties, biosynthesis and intracellular distribution, and possible routes for its degradation and secretion. There is increasing evidence that MT plays an important role in the cellular detoxification of copper, although an involvement in the uptake, storage and transfer of copper has also been proposed. These roles are discussed.

KEY WORDS: • metallothionein • copper • liver • function

Manuscript received 13 May 1986. Revision accepted 18 August 1986.

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