QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Goff, J. P. Articles by Uskokovic, M. R. Search for Related Content PubMed PubMed Citation Articles by Goff, J. P. Articles by Uskokovic, M. R.

Bone Resorption, Renal Function and Mineral Status in Cows Treated With 1,25-Dihydroxycholecalciferol and Its 24-Fluoro Analogues¹

Jesse P. Goff^*, Ronald L. Horst^*,2, E. Travis Littledike^*, A. Boris^,3 and M. R. Uskokovic

^* National Animal Disease Center, Agricultural Research Service, U.S. Department of Agriculture, P.O. Box 70, Ames, IA 50010 Chemical Research Department, Hoffmann-La Roche, Inc., Nutley, NJ 07110

The relative potencies of 1,25-dihydroxycholecalciferol, 24-F-1,25-dihydroxycholecalciferol, and 24,24-F₂-1,25-dihydroxycholecalciferol at three doses (25, 100 or 400 µg) were assessed in nonlactating Jersey cows. The 24,24-F₂-1,25-dihydroxycholecalciferol induced a significantly greater hypercalcemia and hyperphosphatemia than did 1,25-dihydroxycholecalciferol. The 24-F-1,25-dihydroxycholecalciferol was intermediate in its hypercalcemic and hyperphosphatemic potency. Urinary hydroxyproline excretion rate and plasma hydroxyproline concentration were not significantly increased by treatment with any of the compounds. This indicates that these compounds did not stimulate bone resorption in nonlactating, nongravid cows. Renal function was significantly impaired in cows that received a 400-µg dose of any compound. There was a severe reduction in glomerular filtration rate (up to 42%) and urine specific gravity. Renal function was most severely affected in cows treated with 24,24-F₂-dihydroxycholecalciferol and was evident even at the 100-µg dosage level.

KEY WORDS: • 24-F-1,25-(OH)₂D₃ • 24,24-F₂-1,25-(OH)₂D₃ • bovine

¹ This research was supported in part by BARD Grant No. US-352-81.

² Author to whom correspondence should be addressed.

³ Deceased.

Manuscript received 25 February 1985. Revision accepted 17 March 1986.