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Response of Adult Lean and Obese Female Zucker Rats to Intermittent Food Restriction/Refeeding^1,2,

The Hormel Institute, University of Minnesota, Austin, MN 55912

Previously, it was found that lean and obese Zucker rats (9–15 wk of age) responded differently to the first of four cycles of food restriction/refeeding. In later cycles, they responded similarly. The present study was undertaken to determine if this finding was due to age, adaption to the intervention or the obesity. Adult (35-wk-old) lean and obese rats were classified into four groups, ad libitum-fed lean and obese and food-restricted lean and obese. Food-restricted rats underwent four 3-wk periods when they were fed 50% of their ad libitum intake, each followed by a 3-wk period of ad libitum refeeding. Food-restricted rats lost and regained sufficient weight in each cycle to weigh a similar amount as their ad libitum-fed groups by the end of each refeeding period. In lean rats, there were no permanent effects of this intervention except for a 25% reduction in carbohydrate intake. Similar results were found in obese rats, although they did have significantly lower retroperitoneal fat pad weight and serum triacylglycerol levels than ad libitum-fed obese rats at the end of the experiment. These results indicate that lean and obese adult rats respond to each food restriction/refeeding cycle in a similar manner. Results in the earlier experiment would appear to be due both to age and genotype.

KEY WORDS: • lipogenic enzymes • food restriction/refeeding • obesity • adipose tissue cellularity

¹ Supported by National Institutes of Health grant AM-32965 and The Hormel Foundation.

² A portion of these data was presented at the April 1986 Federation of American Societies for Experimental Biology meetings in St. Louis, MO. Cleary, M. P. (1986) Relation of age to the response of lean and obese female Zucker rats to cycles of food restriction/refeeding. Fed. Proc. 45, 350 (abs. 1136).

Manuscript received 26 December 1985. Revision accepted 14 March 1986.

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