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Journal of Nutrition Vol. 116 No. 7 July 1986, pp. 1248-1256
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Lipid and Fatty Acid Composition of Organs from Copper-Deficient Mice1

S. C. Cunnane*, K. R. McAdoo* and J. R. Prohaska{dagger}

* Efamol Research Institute, Kentville, Nova Scotia B4N 4H8, Canada {dagger} Department of Biochemistry, University of Minnesota, Duluth, MN 55812

Experiments were conducted to study the total lipid and fatty acid composition of liver, kidney, brain and heart of 7-wk-old male C57BL mice. Dietary copper deficiency was initiated at birth by feeding dams a purified diet containing 0.5 mg/kg copper. Offspring were fed the copper-deficient diet 4 wk postweaning. Control dams and offspring were fed the same diet but with added copper in the drinking water, 20 mg/L. Compared with controls the copper-deficient mice exhibited hepatomegaly, cardiac hypertrophy and a 4% reduction in brain weight as well as low ceruloplasmin activity (0.5% of control). Total phospholipid concentration in liver and kidney and total triacylglycerol concentration in kidney was lower in copper-deficient mice compared to concentrations measured in liver and kidney of control mice. The major change in essential fatty acid composition in the copper-deficient mice which was consistent between organs and lipid classes was a significantly lower proportion and absolute amount of dihomo-{gamma}-linolenic acid. Other changes in fatty acid composition were variable.

KEY WORDS: • copper-deficient mice • fatty acids • lipids • essential fatty acids

1 Supported in part by BRSG S07 RR 05896 awarded to J. R. Prohaska by the Biomedical Research Support Grant Program, Division of Research Resources, National Institutes of Health.

Manuscript received 7 October 1985. Revision accepted 10 February 1986.






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