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Stable Isotope Studies of Zinc Absorption and Retention in Young and Elderly Men^1,2,

Judith R. Turnlund^*, Ned Durkin, Francoise Costa and Sheldon Margen

^* U.S. Department of Agriculture, Western Regional Research Center, Albany, CA 94710 Western Human Nutrition Research Center, San Francisco, CA 94129 Department of Nutritional Science, University of California, Berkeley, CA 94720

Zinc absorption was determined with ⁶⁷Zn and ⁷⁰Zn, stable isotopes of zinc, in six young men and six elderly men who were confined to a metabolic unit for 12 wk. Their purified formula diets, supplemented with select food items, contained 15 mg of zinc per day. Zinc absorption was determined twice for each subject by combining zinc enriched with either ⁷⁰Zn or ⁶⁷Zn with the formula diet. Serum, urinary, and fecal zinc and zinc balance were determined by atomic absorption spectrometry. Zinc absorption averaged 17% in elderly men, significantly less than average zinc absorption of 31% in young men. Serum zinc was also lower in elderly men and increased in both groups during the course of the study. Zinc balance did not differ between groups, and endogenous zinc losses were less in the elderly than in the young men. The results suggest that while zinc absorption is less in elderly men than in young men, the lower absorption may reflect a lower requirement for absorbed zinc by the elderly. Alternatively, less efficient zinc absorption could result in decreased endogenous losses.

KEY WORDS: • stable isotopes • absorption • zinc • elderly • mass spectrometry

¹ Presented in part at the Federation of American Societies for Experimental Biology meeting, Chicago, IL (1984) Fed. Proc. 43, 850 (abs. 3302).

² Supported in part by USDA Competitive Grant 82-CRCR-1-1072.

Manuscript received 16 September 1985. Revision accepted 24 February 1986.

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