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Effect of Dietary Cystine on Methionine Metabolism in Rat Liver¹

Veterans Administration Medical Center and George Washington University School of Medicine, Washington, DC 20422

Cystine supplementation of adequate diets resulted in significantly higher hepatic levels of betaine-homocysteine methyltransferase. Other changes occurred but were a function of the basal diet. When the latter contained 0.25% methionine + 0.5% cystine, the additional cystine caused a markedly lower hepatic cystathionine synthase activity and lower levels of both adenosylmethionine and serine. The metabolic effect of these changes may be enhanced methionine retention and diminished transsulfuration.

KEY WORDS: • methionine • cystine • cystathionine synthase • betaine-homocysteine methyltransferase

¹ This research was supported by the Veterans Administration and by grant AM 13048 from the National Institutes of Health.

Manuscript received 30 September 1985. Revision accepted 3 February 1986.

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