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Effect of Age and Diet on Cyclic Nucleotide Concentrations in the Intestinal Mucosa of Developing Rats¹

The Research Centre, Departments of Obstetrics & Gynecology and of Pediatrics, University of British Columbia, Vancouver, B.C., Canada V5Z 4H4

Mucosa isolated from the proximal third of the small intestine of infant rats had much lower cyclic nucleotide concentrations (expressed both per unit wet weight and per unit DNA content) than those determined in the intestinal wall. The steady-state concentrations of both cyclic AMP and cyclic GMP in jejunum showed dramatic increases during the first 5 d post partum. Another increase in cyclic nucleotide concentrations was observed in the isolated mucosa between d 15 and 21. Starvation for 24 h always resulted in lower intestinal cyclic nucleotide concentrations than those of the fed littermates. This effect was more pronounced in younger animals and more evident for cyclic AMP values. Three-week-old rats fed a high carbohydrate diet for 24–48 h exhibited more pronounced elevations in the concentrations of cyclic nucleotides from the jejunal mucosa than did rats fed a high fat diet.

KEY WORDS: • cyclic nucleotides • intestinal mucosa • high fat diet • high carbohydrate diet • weaning and development

¹ Supported by the Canadian Medical Research Council and the British Columbia Heart Foundation.

Manuscript received 31 May 1985. Revision accepted 6 January 1986.