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Oral and Intraperitoneal Administration of N-Acetylneuraminic Acid: Effect on Rat Cerebral and Cerebellar N-Acetylneuraminic Acid¹

Department of Pediatrics/Division of Newborn Medicine, University of Mississippi Medical Center, 2500 N. State St., Jackson, MS 39216

Rat pups were administered N-acetylneuraminic acid (NANA) by i.p. injection or via a feeding catheter for eight consecutive days beginning on d 14 of life. All pups were given the identical dose: 1.0 mg on d 1 and 2 and 1.2 mg on the remaining days, or approximately 20 mg/kg body weight per day. A control group was injected i.p. with glucose instead of NANA. On the morning of d 25, pups were decapitated, and the heads were frozen immediately in liquid nitrogen. The brains were later dissected and analyzed for both cerebral and cerebellar ganglioside and glycoprotein NANA. Administration of NANA by both oral and i.p. routes resulted in significantly more cerebral and cerebellar ganglioside and glycoprotein NANA than did glucose injection (with the exception of cerebellar glycoprotein NANA after NANA intubation). There were no significant differences in NANA concentration in these brain fractions for the two routes of NANA administration.

KEY WORDS: • gangliosides • glycoproteins • N-acetylneuraminic acid • cerebrum • cerebellum

¹ This project was supported by BRSG Grant 2 S07 RR05749 awarded by the Biomedical Research Support Grant Program, Division of Research Resources, National Institutes of Health, to the University of South Florida College of Medicine. The work was performed in the Department of Pediatrics, University of South Florida College of Medicine, 12901 N. 30th St., Tampa, FL 33612.

Manuscript received 28 May 1985. Revision accepted 23 December 1985.

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