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Small Intestinal Mucosal Hyperplasia Caused by an Enterokinase Inhibitor from Red Kidney Bean in Rats¹

International Institute for Infant Nutrition and Gastrointestinal Disease, Children's Hospital of Buffalo, 219 Bryant Street, Buffalo, NY 14222 Department of Pediatrics, State University of New York (SUNY) at Buffalo, Buffalo, NY 14214

A specific enterokinase inhibitor (EKI) was purified from red kidney bean (RKB). Male weanling rats fed a diet containing this purified EKI (0.06%) for 6 d showed increases in mucosal weights, protein, DNA and lactic dehydrogenase contents in their small intestines compared to age-matched control rats fed a standard diet. Total mucosal EK and disaccharidase activities were, however, decreased in EKI-fed rats. Thus, oral consumption of EKI from RKB led to small intestinal mucosal hyperplasia in rats. The mucosal hyperplasia observed in EKI-fed rats is not likely due to decreased turnover of mucosal proteins as a result of reduced luminal proteases since luminal contents of trypsin, chymotrypsin and elastase in EKI-fed rats were similar to those of control rats. Enterokinase inhibitor may have a direct hyperplastic effect on the small intestine of rats.

KEY WORDS: • red kidney bean • enterokinase inhibitor • hyperplasia • intestinal enzymes

¹ Supported by a grant from the National Science Foundation no. 21817.

Manuscript received 15 May 1985. Revision accepted 7 January 1986.