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Time-Dependent Changes in Aggregation of Hepatic Ribosomes after Meal Feeding of Rats

Laboratory of Nutritional Biochemistry, Department of Agricultural Chemistry, Nagoya University, Nagoya 464, Japan

The effects of consumption of a meal on changes in aggregation of hepatic ribosomes were studied. Hepatic ribosomes were aggregated very rapidly, within 10–20 min, after meal feeding a 25% caselin diet. This response of hepatic ribosomes is faster than the half-life of mRNAs of some liver proteins. Therefore, when rates are fed, the translational changes in protein synthesis (polysome pattern) might be quickly affected by the dietary protein, and the observed aggregation of ribosomes could indicate the state of protein synthesis in liver in vivo.

KEY WORDS: • polysome pattern • liver protein synthesis • meal feeding • rat

Manuscript received 3 April 1985. Revision accepted 23 October 1985.