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Studies on the Early Changes in Rat Hepatic Fructose 2,6-Bisphosphate and Enzymes in Response to a High Protein Diet^1,2,3,

Centre de Recherches sur la Nutrition du CNRS, 9 rue Jules Hetzel, 92190 Meudon-Bellevue, France

Pertinent hepatic metabolites and enzymes were examined in rats fed a high carbohydrate (HC) diet and during the first 24 h of either starvation or feeding a high protein (HP) diet. Consumption of the HC diet induced slight but definite 24-h oscillations in hepatic concentrations of cyclic AMP, glycogen, glucose 6-phosphate, fructose 2,6-bisphosphate, fructose 1,6-bisphosphate and phosphoenolpyruvate, as well as the activities of 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase and phosphoenolpyruvate carboxykinase. The transition to starvation or the HP diet induced, within 12 h, concurrent increases in cyclic AMP and phosphoenolpyruvate and decreases in glycogen, glucose 6-phosphate, fructose 6-phosphate, fructose 2,6-bisphosphate and fructose 1,6-bisphosphate. These changes were associated with a decrease in the ratio of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase and an increase in phosphoenolpyruvate carboxykinase. These results suggest that the activity of the fructose 6-phosphate/fructose 1,6-bisphosphate cycle is similar during the first 24 h of starvation or HP consumption.

KEY WORDS: • protein • starvation • cyclic AMP • fructose 2,6-bisphosphate • 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase

¹ This work was partially supported by a grant from the Ministee de la Recherche et de l'Industrie (83.C.0446), France.

² This work represents part of a doctoral dissertation submitted by B. Bois-Joyeux to the University of Paris VII.

³ Part of this paper was presented at the 28th meeting of The Canadian Federation of Biological Societies, Toronto, June 17–21, 1985.

⁴ To whom reprint requests should be sent.

Manuscript received 30 July 1985. Revision accepted 28 October 1985.