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Meal-Induced Changes in Lipoprotein Lipase Activity in Brown Fat and Other Tissues of Rats¹

Division of Endocrinology, Metabolism and Nutrition, Departments of Medicine and Pediatrics, Harbor-UCLA Medical Center and the UCLA School of Medicine, Torrance, CA 90509

Brown fat thermogenesis is increased after a single test meal. This study was conducted to determine whether lipoprotein lipase activity is higher in brown adipose and other tissues after a single large meal. Rats were trained to eat two large meals per day. Two hours after consuming a test meal, lipoprotein lipase activity was measured in interscapular brown adipose tissue, retroperitoneal and epididymal white adipose tissue, gastrocnemius and soleus skeletal muscles and heart. After a high carbohydrate test meal, lipoprotein lipase activity in white adipose tissue pads was higher (P < 0.05) and that in brown adipose tissue was lower (P < 0.05) than in these tissues from the meal-deprived group. Muscle lipoprotein lipase did not change significantly. A high fat test meal did not significantly alter lipoprotein lipase activity in brown adipose tissue, white adipose tissue, gastrocnemius or soleus when compared to the meal-deprived control, but heart lipoprotein lipase activity was significantly elevated. These findings indicate that after a single test meal lipoprotein lipase activity in brown adipose tissue is not higher than that from the meal-deprived group and therefore, lipoprotein lipase may not play a rate-limiting role in moving free fatty acids into this tissue in the postprandial state.

KEY WORDS: • brown adipose tissue • lipoprotein lipase • meal feeding

¹ This research was supported by National Institutes of Health (NIH) Nutrition and Metabolism Training Grant T32 AM07461 and NIH grant AM27019.

² Reprint requests should be sent to: Zvi Glick, Ph.D., Harbor-UCLA Medical Center, 1000 West Carson Street, Torrance, CA 90509.

Manuscript received 4 February 1985. Revision accepted 8 November 1985.