Journal of Nutrition

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Journal of Nutrition Vol. 116 No. 3 March 1986, pp. 350-355
Copyright © 1986 by American Society for Nutrition
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Organic Solvent-Soluble Lipofuscin Pigments and Glutathione Peroxidase in Mouse Brain and Heart: Effects of Age and Vitamin E1

B. Zaspel Menken, Le-Chu Su, K. Lund Ayaz and A. Saari Csallany

Department of Food Science and Nutrition, University of Minnesota, 1334 Eckles Avenue, St. Paul, MN 55108

The effect of age and dietary supplementation of vitamin E or N,N'-diphenyl-p-phenylenediamine (DPPD) on organic solvent-soluble lipofuscin pigments (OLP) and glutathione peroxidase (GSH-Px) activity in mouse heart and brain was investigated. Four groups of 32 female weanling mice were fed a basal diet containing either 0, 30 or 300 ppm RRR-{alpha}-tocopheryl acetate (d-{alpha}-tocopheryl acetate) or 30 ppm DPPD from 2 to 18 mo of age. Neither GSH-Px activity nor dietary supplementation of vitamin E or DPPD had an effect on OLP concentrations in the brain or heart. OLP levels were two- to fourfold higher at 12 mo of age in the heart and were lower at 18 mo of age in the brain than at 2 or 9 mo of age. GSH-Px activity increased with age in the heart tissue of vitamin E-deficient and DPPD-supplemented mice only. No change in GSH-Px activity was observed in the brain due to diet or increasing age. These results suggested that OLP concentrations were not affected by dietary supplementation of vitamin E or DPPD but were affected by age-related factors in the mouse brain and heart.

KEY WORDS: • lipofuscin pigments • turnover • vitamin E • glutathione peroxidase

1 Published as Paper No. 10,886 of the Scientific Journal Series of the Minnesota Agricultural Experiment Station on research conducted under Minnesota Agricultural Experiment Station Project No. MN 18-085, supported by Hatch funds and by U.S. Public Health Service, National Institutes of Health (NIH) Grant No. 1 ROI ESO2325.

Manuscript received 21 May 1985. Revision accepted 1 November 1985.






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