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Absorption of Iron from Ferric Hydroxide Polymers Introduced into Ligated Rat Duodenal Segments^1,2,

Louise A. Berner^*, Dennis D. Miller^3,* and Darrell Van Campen

^* Department and Institute of Food Science, New York State College of Agriculture and Life Science, Cornell University U.S. Plant, Soil, and Nutrition Laboratory, Agricultural Research Service, U.S. Department of Agriculture, Ithaca, NY 14853

The availability of iron from ⁵⁹Fe-labeled polymeric ferric hydroxides and low-molecular-weight ferric complexes (LMW iron) was compared by using ligated rat duodenal segments, in vivo. The effect of iron status was assessed by using iron-adequate (Hb 12.3–15.5 g/dl) and iron-deficient (Hb 8.1–10.6 g/dl) rats for each iron treatment. Analysis of data from the animal experiment showed: 1) less (P < 0.01) iron from polymers [6.8% (iron adequate) and 7.7% (iron deficient)] was transferred to the carcass than from LMW iron [29.2% (iron adequate) and 47.9% (iron deficient)] and 2) iron-deficient animals absorbed more iron than iron-adequate rats from LMW iron but not from polymeric iron. Solubility studies showed that these data could not be attributed to solubility differences between polymers and LMW iron. The results of this experiment suggest that in the intestine factors or conditions that depolymerize iron or prevent polymer formation could enhance iron absorption.

KEY WORDS: • iron • ferric hydroxide polymers • iron availability • iron absorption

¹ Supported by U.S. Department of Agriculture Grant No. 82-CRCR-11-004.

² Presented at the 69th Annual Meeting of the Federation of American Societies for Experimental Biology, April 21–26, 1985, Anaheim, CA, Berner, L. & Miller, D. (1985) Absorption of Fe from ferric hydroxide polymers introduced into ligated rat duodenal segments. Fed. Proc. 44, 1851 (abs. 8409).

³ Address reprints to Dennis D. Miller, Department of Food Science, Stocking Hall, Cornell University, Ithaca, NY 14853.

Manuscript received 28 May 1985. Revision accepted 21 October 1985.