QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Eisemann, J. H. Articles by Haaland, G. L. Search for Related Content PubMed PubMed Citation Articles by Eisemann, J. H. Articles by Haaland, G. L.

Effect of Bovine Growth Hormone Administration on Metabolism of Growing Hereford Heifers: Protein and Lipid Metabolism and Plasma Concentrations of Metabolites and Plasma Concentrations of Metabolites and Hormones^1,2,3,4,

Department of Animal Science, Cornell University, Ithaca, NY 14853 ^* Ruminant Nutrition Laboratory, U.S. Department of Agriculture, Agricultural Research Service, Beltsville, MD 20705

The objectives were to determine the effects of daily injection of bovine growth hormone (bGH) on the metabolism of [1-¹⁴C]leucine and [1-¹⁴C]palmitate and on hormone and metabolite concentrations in growing Hereford heifers. The experimental design was a 28-d single reversal with two 14-d injection periods of placebo or bGH. Energy intake was restricted to a level slightly above maintenance. Injection of bGH did not affect circulating concentrations of glucose, ß-hydroxybutyrate, urea nitrogen, prolactin, triiodothyronine or thyroxine. Plasma concentrations of insulin and nonesterified fatty acids (NEFA) were chronically elevated whereas leucine concentration was chronically decreased after 1 wk of bGH injection compared to placebo injection. Leucine oxidation was lower and whole-body protein synthesis was higher during bGH injection than during placebo injection. There were increases in both total irreversible loss and oxidation of NEFA during bGH injection compared to placebo injection. These results suggest mobilization of stored fatty acids and increased reliance on NEFA to provide energy for cellular processes. The dual and reciprocal effects of bGH on nitrogen and NEFA metabolism demonstrate its role as a homeorhetic regulator, affecting metabolism of several body tissues to support lean body accretion in Hereford heifers at near-maintenance intake of metabolizable energy.

KEY WORDS: • growth hormone • cattle • leucine • palmitate • hormone • metabolite

¹ The authors would like to express appreciation to The Upjohn Company for providing the bGH used in this study.

² Presented in part at the 76th Annual Meeting of the American Society of Animal Science, August 1984, University of Missouri, Columbia, MO; the 6th International Symposium on Ruminant Physiology, September 1984, Banff, Alberta, Canada, and the 18th Annual Meeting of the Midwestern Section of the American Society of Animal Science, March 1985, Chicago, IL. Abstract published in J. Anim. Sci. 59(Suppl. 1), 219, 1984; Can. J. Anim. Sci. 64(Suppl.), 308–309, 1984, and J. Anim. Sci. 61(Suppl. 1), 121, 1985.

³ Supported in part by USDA Cooperative Agreement No. 58-32U4-3-453, The Upjohn Company, American Cyanamid Company and Monsanto Industrial Chemicals Company.

⁴ Mention of a trademark or proprietary product does not constitute a guarantee or warranty of the product by the U.S. Department of Agriculture and does not imply its approval to the exclusion of other products that may also be suitable.

⁵ Present address: USDA-ARS, Roman L. Hruska U.S. Meat Animal Research Center, P.O. Box 166, Clay Center, NE 68933. To whom reprint requests should be addressed.

⁶ Present address: USDA-ARS, Subtropical Agricultural Research Station, P. O. Box 246, Brooksville, FL 33512.

⁷ Deceased.

Manuscript received 17 December 1985. Revision accepted 27 June 1986.

This article has been cited by other articles:

				J. C. Velez and S. S. Donkin Bovine Somatotropin Increases Hepatic Phosphoenolpyruvate Carboxykinase mRNA in Lactating Dairy Cows J Dairy Sci, May 1, 2004; 87(5): 1325 - 1335. [Abstract] [Full Text] [PDF]

				J. A. Bush, D. G. Burrin, A. Suryawan, P. M. J. O'Connor, H. V. Nguyen, P. J. Reeds, N. C. Steele, J. B. Van Goudoever, and T. A. Davis Somatotropin-induced protein anabolism in hindquarters and portal-drained viscera of growing pigs Am J Physiol Endocrinol Metab, February 1, 2003; 284(2): E302 - E312. [Abstract] [Full Text] [PDF]