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Beneficial Effect of Moderate Protein Restriction on Growth, Renal Function and Survival in Young Rats with Chronic Renal Failure¹

University of Wisconsin, Department of Pediatrics, Clinical Sciences Center, Madison, WI 53792

We used the model of one-stage uninephrectomy and contralateral heminephrectomy to study the effect of protein restriction on growth and renal function in young (starting age 21 d) female rats. Normal, sham-operated, pair-fed, and chronic renal insufficiency (CRI) rats were fed a 6, 14 or 22% protein (casein) diet. Diets were otherwise isoenergetic and equivalent in sodium, potassium, chloride, phosphate and calcium. Weight, length, urinary protein and creatinine clearances were measured up to 6 mo of age. Regardless of group (normal, sham or CRI), animals fed a 6% protein diet weighed less and were shorter than animals fed 14 or 22% protein diets. No difference in growth could be found between 14 and 22% protein intake. However, animals with CRI fed 22% protein diet had a shorter survival time than animals fed 14 or 6% protein diets. Six percent protein intake led to a lower growth rate over the first 10–12 wk of age than 14 or 22% protein intake. We conclude that 14% protein intake in rats with CRI maintains normal growth and improves survival over 22% protein intake. Rats with CRI fed a 6% protein diet have improved survival compared to rats fed a 22% protein diet but suffer growth retardation.

KEY WORDS: • protein restriction • growth • renal insufficiency

¹ These studies were supported in part by the National Kidney Foundation of Wisconsin and the University of Wisconsin Medical School and Graduate School Research Committees.

Manuscript received 22 July 1985. Revision accepted 27 June 1986.

This article has been cited by other articles:

				J. D. Hanna, J. W. Foreman, and J. C.M. Chan Chronic Renal Insufficiency in Infants and Children Clinical Pediatrics, June 1, 1991; 30(6): 365 - 384. [PDF]