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Pancreatic Enzyme and Plasma Cholesterol Response to Chronic Ingestion of a Nonabsorbable Lipid in Rats¹

Consumer Science and Nutrition Department, College of Mount St. Joseph, Mount St. Joseph, OH 45051 and Department of Nutrition, University of California, Davis, Davis, CA 95616

Pancreatic enzyme activity and plasma and high density lipoprotein (HDL) cholesterol levels were measured in rats chronically fed a nonabsorbable lipid, sucrose polyester (SPE), to determine if the rat pancreas responds to SPE as a dietary lipid or a nonnutritive ingredient. Adult male rats were fed for 28 d a diet containing either 5% or 20% corn oil, 5% SPE, 16% and 4% hydrogenated palm oil (HPO), or 16% corn oil and 4% HPO. HPO is used to prevent anal leakage of unabsorbed oil when SPE is fed at high dietary levels. Since HPO and SPE are not absorbed, rats fed SPE derive their energy from protein and carbohydrate in the diet. The tissue levels of pancreatic enzymes in rats consuming high levels of SPE in the diet resemble those of rats eating a low fat diet in which energy is derived from carbohydrate and protein. Plasma and HDL cholesterol levels were lowest in the group consuming high levels of SPE, an observation that is consistent with previous reports. These data indicate that the pancreas responds to SPE as a nonnutritive ingredient rather than a digestible dietary lipid.

KEY WORDS: • pancreatic enzymes • sucrose polyester • plasma cholesterol • amylase • lipase

¹ Presented in part at the 1984 meeting of the Federation of American Societies for Experimental Biology, St. Louis, MO. Fed. Proc. 43, 482.

² To whom reprint requests should be addressed.

Manuscript received 24 February 1986. Revision accepted 17 July 1986.