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Diets Varying in Linoleic and Linolenic Acid Content Alter Liver Plasma Membrane Lipid Composition and Glucagon-Stimulated Adenylate Cyclase Activity1

Laura A. Morson* and Michael T. Clandinin2,{dagger}

* Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, M5S 1A8 {dagger} Department of Nutrition and Metabolism Research Group, University of Alberta, Edmonton, Alberta, T6G 2M8, Canada

Male Sprague-Dawley rats were fed diets varying in fatty acid composition for 24 d. Liver plasma membranes were isolated, and the effect of diet on phospholipid fatty acyl tail composition and glucagon-stimulated adenylate cyclase activity was measured. Dietary linolenic acid influenced membrane phospholipid fatty acid composition and altered the effect of different dietary levels of linoleic acid on membrane composition. At low dietary intakes of linolenic acid, membrane fatty acids derived from linolenic acid increased as dietary intake of C18:2(9,12) increased. At high dietary linolenic acid levels membrane content of fatty acids derived from linolenic acid decreased as dietary intake of linoleic acid increased. Glucagon-stimulated adenylate cyclase activity decreased at high levels of both dietary linoleic acid and linolenic acid. These observations suggest that dietary balance between linoleic and linolenic acids has a role in plasma membrane composition and may control glucagon-stimulated adenylate cyclase activity.

1 The authors acknowledge the financial support of the Natural Sciences and Engineering Research Council of Canada and the Farming for the Future program of the Alberta Agricultural Research Council.

2 Reprint requests should be directed to Dr. M. T. Clandinin, Departments of Foods & Nutrition and Medicine, 318 Home Economics Building, University of Alberta, Edmonton, Alberta, Canada T6G 2M8, (403) 432-5349.

Manuscript received 25 June 1985. Revision accepted 27 June 1986.






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