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Alteration in Lipoprotein Composition with Intravenous Compared to Intragastric Fat-Free Feeding in the Rat^{1, 2,}

Department of Nutrition, University of California, Davis, CA 95616

Rats were fed continuously for 7 d with fat-free total parenteral nutrition solutions delivered intravenously (IV) or intragastrically (IG) to determine changes in plasma lipoprotein composition due to elimination of intestinal nutrient absorption. IV feeding resulted in significantly lower plasma levels of apoA-I and A-IV, which are synthesized by the intestine, and in a 40% reduction in the weight of intestinal mucosa. Higher apoE levels in plasma, a greater proportion of apoE-enriched HDL₁ particles and proportionately more HDL cholesterol were observed in IV- than in IG-fed animals. IV feeding also resulted in lower apoC-II levels in the HDL fraction. These differences in plasma apolipoprotein and HDL composition suggest alterations in lipoprotein metabolism with IV compared to IG feeding in the rat.

KEY WORDS: • apolipoprotein • TPN • HDL • enteral feeding • apoE • apoA-I • cholesterol • triglycerides

¹ This work was supported in part by Grant AM-20446 from the National Institutes of Health.

² Some of this work has been published as an abstract. Ney, D., Lefevre, M. & Schneeman, B. O. (1984) Alteration in HDL composition with fat-free TPN in the rat. Fed. Proc. 43, 796, (abs. 2989).

³ Current address: Department of Nutritional Sciences, University of Wisconsin-Madison, 1415 Linden Dr., Madison, WI 53706.

⁴ Current address: Department of Physiology, LSU Medical Center, New Orleans, LA 70112.

⁵ To whom reprint requests should be addressed.

Manuscript received 7 October 1985. Revision accepted 16 June 1986.