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Neuropeptides as Regulators of Consummatory Behaviors

A. S. Levine, J. E. Morley, B. A. Gosnell, C. J. Billington and D. D. Krahn

Neuroendocrine Research Laboratory, Veterans Administration Medical Center, Minneapolis, MN 55417, the Department of Food Science and Nutrition, University of Minnesota, St. Paul, MN 55108 and the Geriatric Research, Education and Clinical Center, VA Medical Center, Sepulveda, CA 91343

The control of ingestive behavior involves a variety of neurotransmitters, including monoamines, peptides and amino acids. For the past decade many investigators have focused their research on the role that regulatory peptides play in eating behavior. Many peptides, including cholecystokinin, bombesin, calcitonin, corticotropin-releasing factor, neurotensin and somatostatin, have been reported to decrease the amount of food ingested by laboratory animals. In contrast, a relatively small number of peptides increase food intake. The present review describes the effects of these peptides on consummatory behaviors in various species and their sites of action.


KEY WORDS: • neuropeptides • eating behavior • neurotransmitters

Manuscript received 10 January 1986. Revision accepted 16 June 1986.







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