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Effects of Dehydroepiandrosterone Acetate on Metabolism, Body Weight and Composition of Male and Female Rats^1,2,

Human Nutrition Center, Department of Animal and Nutritional Sciences ^* Department of Psychology, University of New Hampshire, Durham, NH 03824

Twenty adult Sprague-Dawley outbred rats (10 male and 10 female) were fed a nonpurified diet without or containing dehydroepiandosterone acetate (DHEA 6 g/kg diet) for 11 w. DHEA-treated animals weighed less than the controls after 6 wk and until the end of treatment. However, only the differences between male groups were statistically significant. Food intake of the DHEA-fed animals was not affected, but resting heat production was elevated for both sexes. Serum triglyceride levels and activity of hepatic glucose-6-phosphate dehydrogenase of the experimental groups were lower than controls. Analyses of body composition indicated DHEA-treated animals had proportionately less body fat and therefore more body water, protein and ash than controls. In most cases, differences in body composition were due primarily to effects of DHEA on the female animals. In a second experiment, DHEA treatment did not alter urinary ketone levels nor did it enhance citrate synthase activity in interscapular brown fat, skeletal muscle, heart or liver. Findings suggest that DHEA acetate treatment affected body weight, body composition and utilization of dietary energy by both impairing fat synthesis and promoting fat-free tissue deposition and resting heat production. Possible mechanisms by which DHEA may affect metabolism are discussed.

KEY WORDS: • dehydroepiandrosterone • body weight • body fat • body composition • resting metabolism • food intake • lipid metabolism

¹ Supported in part by New Hampshire Agricultural Experiment Station Project Number H260 and by NIH Grant 1R23AM31549. Scientific Contribution Number 1422 from the New Hampshire Agriculture Experimental Station.

² Part of study was presented at the 67th Annual Meeting of the Federation of American Societies for Experimental Biology, April 10–15, 1983, Chicago, IL.

Manuscript received 14 January 1985. Revision accepted 15 May 1986.

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