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Similar Effects of Zinc Deficiency and Restricted Feeding on Plasma Lipids and Lipoproteins in Rats1

Barbara O. Schneeman2, Dee Lacy3, Denise Ney, Michael L. Lefevre3,4,, Carl L. Keen, Bo Lönnerdal and Lucille S. Hurley

Department of Nutrition, University of California, Davis, CA 95616

The objective of this study was to determine whether alterations in HDL composition observed previously were due specifically to zinc deficiency or to reduction in food intake. Rats were placed into three groups and fed for 21 d a zinc-adequate diet (100 ppm) ad libitum, or a zinc-deficient diet (< 1 ppm) ad libitum, or the zinc-adequate diet at an intake equal to that of the deficient group. Blood plasma was fractionated into VLDL, LDL and HDL fractions, and plasma and the isolated fractions were analyzed for lipids and apolipoprotein composition. Analysis of plasma and liver zinc indicated that animals consuming the low zinc diet were deficient. Zinc deficiency and restricted feeding were associated with lower plasma and VLDL triglyceride levels and lower HDL cholesterol levels. The similarities in overall pattern of lipoprotein composition between the zinc-deficient and restricted-intake groups indicate that reduction in food intake may account for the differences in lipoprotein composition which were observed.

KEY WORDS: • lipoproteins • zinc deficiency • apolipoproteins

1 This work has been supported by grants from the National Institutes of Health (AM-20446 and HD-01743) and from the California Affiliate of the American Heart Association.

2 To whom reprint requests should be addressed.

3 Supported by fellowships from the California Affiliate of the American Heart Association.

4 Present address is Department of Physiology, LSU Medical Center, New Orleans, LA 70112.

Manuscript received 9 January 1986. Revision accepted 8 May 1986.






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