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Metabolism in Rats of Selenium from Intrinsically and Extrinsically Labeled Isolated Soy Protein

Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907

Absorption, retention and tissue accumulation by rats of ⁷⁵Se from intrinsically labeled isolated soy protein were compared with utilization of ⁷⁵Se from the extrinsic sources of [⁷⁵Se]selenite, [⁷⁵Se]selenate or [⁷⁵Se]selenomethionine. Extrinsic sources of selenium were given by gavage or mixed with isolated soy protein. There were no differences in absorption and retention of ⁷⁵Se from intrinsically labeled soy diet compared to the three extrinsically labeled soy diets. Of the three extrinsic sources tested, ⁷⁵Se from selenate was better absorbed than from selenite or selenomethionine when incorporated into a soy diet. Absorption of ⁷⁵Se was significantly lower when given to animals in gavage solution than when mixed with soy diets. After a 14-d test period, retention of ⁷⁵Se was the same for all four soy diet groups. In gavaged groups, ⁷⁵Se from selenomethionine was retained to a greater extent than ⁷⁵Se from selenite. The liver, testes and kidney accumulated more ⁷⁵Se from the test meal than did the blood and lungs. In the testes more ⁷⁵Se from selenite and selenate was accumulated than from selenomethionine-labeled diets. Selenium absorption from the soy isolate source was very high (86–96%), indicating that, although soy does not normally contain high levels of selenium, the selenium present is well absorbed from this plant source.

KEY WORDS: • selenium • intrinsic label • extrinsic label • absorption • retention

Manuscript received 28 October 1985. Revision accepted 25 April 1986.