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Effect of Vitamin B-6 Deficiency on Plasma Amino Acid Levels in Chronically Azotemic Rats1

Marsha Wolfson, Stewart A. Laidlaw, Reinhild M. Flugel-Link, Christy J. Strong, Isidro B. Salusky and Joel D. Kopple

Veterans Administration Medical Center and Oregon Health Sciences University, Portland, OR 97207 and UCLA School of Medicine, Harbor-UCLA Medical Center, Torrance, CA 90209

Chronic renal failure is associated with many abnormalities in plasma amino acids. Since patients with renal failure are frequently deficient in vitamin B-6, this study examined whether vitamin B-6 deficiency may be a cause of any of the abnormal plasma amino acid concentrations observed in chronic renal failure. Sham-operated and chronically azotemic rats were pair-fed diets deficient in or replete with vitamin B-6 for 21 d. By the end of 21 d, the EGOT index rose significantly in the B-6-deficient rats but not in the B-6-replete animals. There were several differences in plasma amino acid concentrations between azotemic and control rats. Azotemia and B-6 deficiency each lowered the plasma serine concentration and raised the glycine-to-serine ratio. Plasma glycine was affected by a two-way interaction between azotemia and vitamin B-6 deficiency whereby the highest values were found in the sham-operated vitamin B-6-deficient animals. Plasma alanine and asparagine were reduced by B-6 deficiency and unchanged by azotemia. These results suggest that vitamin B-6 deficiency may contribute to several of the abnormalities in the plasma aminograms observed in chronic renal failure.

KEY WORDS: • vitamin B-6 deficiency • azotemia • renal failure • uremia • nutrition in renal disease

1 Preliminary reports of portions of this were published in Kidney Int. 23, 165A, 1983 and in Clin. Res. 31, 66A, 1983.

Manuscript received 18 October 1985. Revision accepted 24 April 1986.






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