QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ahrens, F. Articles by Barth, C. A. Search for Related Content PubMed PubMed Citation Articles by Ahrens, F. Articles by Barth, C. A.

Effects of Oral and Intracecal Pectin Administration on Blood Lipids in Minipigs¹

Institut für Physiologie und Biochemie der Ernährung, Bundesanstalt für Milchforschung, D-2300 Kiel, West Germany

The effects on blood lipids of oral and intracecal pectin administration for 4 wk were examined in six male adult hypercholesterolemic minipigs (total serum cholesterol = 8.4 mmol/L). The pigs were fitted with a cecal cannula and were assigned to three groups of two pigs each; the groups underwent an experiment in 3 x 3 Latin square design. The control period was designated as that during which water was infused into the cecum. Total serum cholesterol concentration was about 50% lower after feeding 75 g pectin per day than during the control period. The intracecal infusion of the same amount of pectin had no effect on total serum cholesterol concentration compared to the control period. The cholesterol level in the low density lipoproteins (LDL), in the very low density lipoproteins (VLDL) and in the high density lipoproteins (HDL) was lower after feeding pectin than in the control period. The HDL cholesterol, but not LDL or VLDL cholesterol, was at a lower level after intracecal infusion of pectin than during the control period. Thus, the study clearly demonstrates that the passage of pectin through the small intestine is necessary for its hypocholesterolemic action.

KEY WORDS: • dietary fiber • mechanism • pectin • serum lipids • large bowel

¹ Part of this work was presented at the 21st Scientific Meeting of the German Society of Nutrition, Bonn, March 29th and 30th, 1964, West Germany and was published as an abstract: Ahrens, F., Hagemeister, H., Pfeuffer, M. u. Barth, C. A. (1984) Orale und intracecale Wirkungen von Pektin auf den Serumcholesterinspiegel.—Ein Beitrag zum Wirkort von Ballaststoffen. Ernährungsumschau 31, 273.

² Present address: I. S. Forschungsgesellschaft, Wiesenweg 10, D-2362 Wahlstedt, West Germany.

Manuscript received 28 January 1985. Revision accepted 23 September 1985.

This article has been cited by other articles:

				J. M. W. Wong and D. J. A. Jenkins Carbohydrate Digestibility and Metabolic Effects J. Nutr., November 1, 2007; 137(11): 2539S - 2546S. [Abstract] [Full Text] [PDF]