QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Purchase Article View Shopping Cart Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Demigné, C. Articles by Rémésy, C. Search for Related Content PubMed PubMed Citation Articles by Demigné, C. Articles by Rémésy, C.

Enhanced Uptake of Insulin and Glucagon by Liver in Rats Adapted to a High Protein Diet

Laboratoire des Maladies Métaboliques, Institut National de la Recherche Agronomique, Theix, 63122 Ceyrat, France

The regulatory role of the liver with regard to circulating concentrations of insulin and glucagon was investigated in rats adapted to high carbohydrate (HC) or high protein (HP) diets, during the period of maximal nutrient absorption. In rats fed HC diet, high secretion of insulin into portal vein in conjunction with low hepatic uptake elicited systemic hyperinsulinemia. In rats fed HP diet, both insulin and glucagon were secreted in large amounts, but hormone removal by the liver was greater than in rats fed the HC diet. Hepatic fractional extraction was higher for insulin than for glucagon: systemic insulin/glucagon ratio was, therefore, lower than the portal insulin/glucagon ratio. Binding of insulin and glucagon to hepatocyte cell membranes was lower in rats fed HP diet than in those fed the HC diet: this could correspond in vivo to a higher rate of internalization of occupied receptors since affinities of the receptors were unchanged. The results indicate that in rats adapted to HP diets the liver undergoes specific adaptations for regulation of peripheral insulin/glucagon levels, along with its role of target tissue for these hormones.

KEY WORDS: • insulin • glucagon • hepatic extraction • high protein diet

Manuscript received 14 January 1985. Revision accepted 8 April 1985.

This article has been cited by other articles:

				D. Azzout-Marniche, C. Gaudichon, C. Blouet, C. Bos, V. Mathe, J.-F. Huneau, and D. Tome Liver glyconeogenesis: a pathway to cope with postprandial amino acid excess in high-protein fed rats? Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2007; 292(4): R1400 - R1407. [Abstract] [Full Text] [PDF]