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Effect of Wheat Bran, Pectin and Cellulose on the Secretion of Bile Lipids in Rats¹

H. Lafont, D. Lairon, J. L. Vigne, F. Chanussot, C. Chabert, H. Portugal^*, A. M. Pauli^*, C. Crotte and J. C. Hauton

Unité 130—INSERM (Institut National de la Santé et de la Recherche Médicale), 10, avenue Viton, 13009 Marseille, France ^* Laboratoire Central, Hôpital Ste-Marguerite, 13009 Marseille, France Unité 31 — INSERM, 46, Boulevard de la Gaye, 13009 Marseille, France

We assayed the lipid content of bile from rats that had been fed either a standard diet (5% fat) or a high fat diet (25% fat, 1.2% cholesterol) in the presence or in the absence of various dietary fibers (namely, wheat bran, pectin and cellulose). The cholesterol concentration in bile from rats fed the high fat diet plus wheat bran or pectin was lower than that of the rats fed the high fat, high cholesterol diet without fiber. Bile phospholipids did not vary significantly from one group to another. In comparison to the standard diet, the high fat, high cholesterol diet led to a greater ratio of primary to secondary bile salts and a higher level of glycoconjugates. The observed differences may be explained by a variation in the metabolism of bile salts brought about by the difference in diet.

KEY WORDS: • dietary fibers • cellulose • bran • pectin • standard diet • high fat, high cholesterol diet • bile lipids

¹ Supported by a grant from the Délégation Générale à la Recherche Scientifique et Technique (DGRST Grant No. 80.7.0116).

Manuscript received 2 May 1984. Revision accepted 29 March 1985.