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Tin, Copper, Iron and Calcium Metabolism of Rats Fed Various Dietary Levels of Inorganic Tin and Zinc^1,2,

Department of Nutritional Sciences, University of Wisconsin, Madison, WI 53706

Three studies were conducted to determine the effects of various dietary levels of tin (<1, 100, 200, 500, 2000 µg/g diet) and of zinc (15, 30, 52 µg/g diet) on the metabolism of tin, copper, iron and calcium by growing rats. The accumulation of tin in the kidneys and tibias of animals was proportional to dietary exposure. The concentration of tin in the bones of rats fed >100 µg Sn/g diet was 5-fold and 20-fold greater than the levels found in kidney and liver, respectively. Rats fed >500 µg Sn/g diet had plasma copper levels that were only 13% of control levels and had depressed copper levels in livers and kidneys. The activity of -aminolevulinic acid dehydratase in the erythrocytes of rats fed the highest level of tin was 55% of that found in control animals. The amounts, but not the concentrations, of calcium in the tibias of rats fed >100 µg Sn/g diet were less than the levels in the bones of control animals. The moderate variations in dietary zinc levels did not affect significantly the levels of minerals in tissues.

KEY WORDS: • tin • zinc • copper • iron • calcium • -aminolevulinic acid dehydratase

¹ Supported by the College of Agricultural and Life Sciences, University of Wisconsin, Madison, WI, Project No. 2623, U.S. Department of Agriculture Competitive Research Grant No. 59-2551-1-1-602, and the University of Wisconsin Graduate School.

² Presented in part at the annual meeting of the Federation of American Societies for Experimental Biology, St. Louis, MO, April 1984. Johnson, M. A. & Greger, J. L. (1984) Tin, copper, iron and calcium metabolism of rats fed various dietary levels of inorganic tin and zinc. Fed. Proc. 43, 680 (abs. 2314).

³ Current address: Department of Foods and Nutrition, University of Georgia, Athens, GA 30602.

⁴ To whom reprint requests should be sent.

Manuscript received 15 October 1984.