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In Vivo Intestinal Absorption of Selenate and Selenite by Rats¹

Institut für Veterinärphysiologie der Universität Zürich, Winterthurerstrasse 260, 8057 Zürich, Switzerland

Intestinal absorption of selenate and selenite was investigated in rats by using an in vivo perfusion technique. Different segments of the intestine were perfused with an isotonic solution containing different concentrations of SeO₄^2- or SeO₄^2-. The site of greatest SeO₄^2- absorption was found to be the ileum followed in descending order by the proximal jejunum and large intestine (cecum and colon). Furthermore, SeO₄^2- was absorbed significantly faster from the ileum than SeO₄^2-. The concentration dependence of SeO₄^2- absorption indicates that SeO₄^2- is absorbed by a saturable transport mechanism of the ileal mucosa. Absorption of SeO₄^2- at a concentration of 0.01 mM was not affected by the presence of 1 mM SeO₄^2- in the perfusate. When the SeO₄^2- concentration of the perfusate was increased to 1 mM, the absorptive functions of the ileal epithelium appeared to be generally impaired. It is concluded that selenate is absorbed from the ileum by a carrier-mediated mechanism.

KEY WORDS: • selenate • selenate • intestinal absorption

¹ The investigation was supported by the Schweizerischer Nationalfonds (Grant No. 3.937-0.84).

Manuscript received 19 July 1984.

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